مقایسه اثرات درمانی و عوارض داروئی والپروات سدیم و پروپرانولول در پیشگیری از سردردهای میگرنی کودکان

One of the causes of frequent headaches in children is migraine headache. The prevention of headaches , will improve life equality in children. This study was designed to compare between treatment and side effects of sodium valproate and propranolol in preventing migraine headaches. This study was a randomized controlled clinical trial which carried out on 52 children who were reffered to out patient neurology clinic of the Ekbatan and Sina hospitals. All children with migraine who had headache during last 6 months were enrolled, and those who had received sodium valproate and propranolol previously, were excluded. The method was convenience sampling and the patients were divided into two groups with 26 patients: A and B for propranolol and sodium valproate respectively.    Group A treated with propranolol and group B with sodium valproate for 8 weeks. The response to treatment was evaluated after 4 weeks. The study evaluated 52 children with migraine from 7-15 year’s old , 38.5% of cases were male and 61.5% female. Before treatment , the mean number of attacks was 5.61 months in group A and 8.73 months in group B. After treatment the number of attacks was declined in 21 cases (80.8%) of group A and 19 cases (73.1%) of group B. Severity of pain was improved in 18 cases (69.2%) of group A and 15 cases (57.7%) of group B. The incidence of vertigo was 3 cases (11.5%) in group A and 2 cases (7.7%) in group B. Abnormal liver enzymes test were detected in 11.5% of cases in the group B. CBC was abnormal in 7.7% of cases in the group B            Sodium valproate and propranolol , both have the same therapeutic effects in prevention of migraine headeache in children. But side effects are different , and choice of either one depended on the effects consideration and contraindications of each one.